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Complementary preclinical work by Sanchez-Garrido and colleagues evaluated these conjugates in models of metabolic and hormonal dysfunction, identifying molecular changes across pathways directly implicated in neurodegeneration [25]

GIP and GLP-1 exert their effects by binding to their specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), which belong to the G-protein coupled receptor family