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Pedersen JS

These drugs work by targeting GLP-1, a satiety hormone that has been shown to support significant weight loss by quieting hunger signals in the brain while simultaneously slowing digestion

281 Analyses of social media suggest that off-label use is influenced by dosing concerns, insurance denials, and GI side effects

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Considering the diversity of clinical trials and indications they are tested in including the notoriously challenging Alzheimers disease these claims may well hold a substantial amount of truth (Table 1)

Carrying significant extra weight increases the risk of type 2 diabetes, cardiovascular disease, and future pregnancy complications