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However, integrating the established effects of GLP-1-associated weight loss on fat-free mass with the anabolic effects of TRT in men with low testosterone concentrations raises a clinically relevant and mechanistically plausible question: whether normalization of androgen levels in selected patients may contribute to lean mass preservation during pharmacologically induced weight reduction

They stimulate glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying, and promote satiety through central nervous system effects