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Sci Transl Med 5:209ra151 Finan B, Yang B, Ottaway N et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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Unlike injectable obesity drugs, which are peptides designed to mimic the appetite-controlling GLP-1 hormone, orforglipron is a small molecule pill that is easier to manufacture and package, said Kenneth Custer, president of Lilly's cardiometabolic health division

However, this can lead to increased blood flow, better oxygen and nutrient delivery in the tissues

Stimulation of Insulin Secretion (-cells) When GLP-1 RAs bind to receptors on pancreatic -cells, they activate adenylate cyclase (AC), increasing intracellular cyclic AMP (cAMP)

Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article