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GLP-1s Direct Biological Impact in the Brain Beyond their systemic metabolic effects, GLP-1 medications exert direct biological actions in the brain through widespread expression of incretin (GLP-1) receptors in regions critical for cognition, including the hippocampus, prefrontal cortex, and hypothalamus [14]

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Guinane C, Tadrous A, Fouhy F, et al

55 However, the ASA statement has been criticised based on lack of supportive data

Healthcare providers should establish clear communication channels for patients to report concerns and should conduct regular follow-up assessments, particularly during dose titration periods when adverse effects are most likely to emerge

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