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And GLP-1 patches are being developed that could offer transdermal delivery as an alternative to weekly injections

However, for a small number of patients, nausea symptoms may persist and even affect their daily life and medication adherence

Studies have shown that activation of the TGF-/Smad3 signaling pathway promotes collagen deposition, increases myocardial stiffness, and drives fibrotic remodeling [48]

The FDA declared the semaglutide shortage resolved in February 2025 and the tirzepatide shortage resolved in late 2024, which ended the shortage-list justification that most large-scale compounding relied on

doi:10.1530/JOE-16-0598 46

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