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Males: young onset with severe LVH/HCM and extracardiac phenotype Females: isolated cardiomyopathy (can be either dilated or hypertrophic) with preexcitation arrhythmias with a family history suggesting X-linked dominant transmission (i.e., males more severely affected than females)

Also worth noting these are relative risk reductions

Its more than just bad acne painful nodules, abscesses, scarring, and what are called sinus tracts or fistulas, which are tunnels running back into the body.[ref] HS affects the areas of the body that contain apocrine glands (armpits, groin, and around the nipple) and the perianal area

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[i] Ozempics popularity with celebrities, influencers, and the public alike has seen demand spiral, taking the manufacturer by surprise and leading to worldwide shortages