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Alcohol Clin Exp Res (Hoboken)

Appetite Regulation GLP-1 activation slows gastric emptying and acts on hypothalamic satiety centers, reducing overall caloric intake without willpower-driven restriction

In STEP 1 and SURMOUNT-1, semaglutide and tirzepatide produced large, durable reductions in body weight, setting a new efficacy benchmark for pharmacotherapy [1,2]

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In comparison with naturally occurring receptor ligands, retatrutide has lower potency at the human glucagon and GLP-1 receptors, at approximately 0.3- and 0.4-fold, respectively, while showing markedly greater potency at the human GIP receptor, at about 8.9-fold