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In the ATTAIN obesity trials, maintenance doses of 6 mg, 12 mg, and 36 mg were evaluated, with 36 mg producing the greatest weight loss

One way to improve the situation would be for Congress to remove FDA barriers to compounding pharmacies making products that are essentially copies of commercially available off-patent products

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2023a;138(2):13251

But the musculoskeletal data is real and cannot be ignored

Additionally, in phase 2 studies in people with MASH and liver fibrosis, survodutide not only significantly improved liver steatosis, but also led to histologic improvement of MASH without worsening fibrosis in 4362% of participants, versus 14% with placebo [41]