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Evidence-based management starts with the mildest effective intervention and steps up as needed

Published comparator research reports approximately 22.5% body weight reduction for tirzepatide (dual receptor agonist) and approximately 15% for semaglutide (single receptor agonist) in their respective trials

Small errors in what youre actually injecting are not small errors in effect

PIONEER 6 PIONEER 6 was a randomized, double-blind, placebo-controlled trial comparing oral semaglutide to placebo designed to rule out an excess in cardiovascular risk with oral semaglutide among patients with T2DM

doi: 10.1186/s13059-016-1070-5

DiStefano MJ et al