how does glp 1 agonist work GLP-1 and Anesthesia: Considerations and Cautions for CRNAs Actions of GLP-1 in peripheral

Description

The study found that there was a statistically significant weight and visceral fat reduction in the group receiving the dose of 15mg/day after 4 weeks of the intervention (4)

HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]

Oral GLP-1 agonists havent quite caught on yet, primarily due to (1) issues with absorption, which necessitates higher dosing than injectables and may impact efficacy, and (2) fasting restrictions (must be taken on an empty stomach)