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But they are changing the landscape of medicine because they hit a fundamental biology we have ignored for too long: the gut-brain-metabolic axis

Samms RJ, Kusminski CM

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Key contraindications include: Personal or family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type 2 (MEN2) : Animal studies show a link to thyroid tumors, so these drugs are avoided to prevent potential risks

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Ongoing research aims to develop additional oral GLP-1 medications that may offer improved efficacy and convenience