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Trials are being executed to investigate Ozempics use as treatment for glucose intolerance in women with prior gestational diabetes mellitus (GDM)

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Key findings from OASIS 4 Double-blind, placebo-controlled, 64-week, phase 3 trial (N=307) Mean weight loss: 13.6% (semaglutide) vs 2.2% (placebo) 5% weight loss in 79.2% (semaglutide) vs 31.1% (placebo) Improvements in physical functioning and cardiometabolic markers Serious adverse events were lower in the semaglutide group (3.9% vs 8.8%) This could be a key player particularly among patients who are needle-averse, travel often, or seek simpler dosing options

The long-term safety of inhaled GLP-1 also needs to be established since GLP-1 receptors are abundantly expressed in pulmonary tissue

Looking ahead, future research endeavors should focus on conducting well-designed clinical trials, mechanistic studies, comparative effectiveness research, health economic analyses, and patient-centered outcomes research to further elucidate Semaglutides role in lupus management

& Garry, R