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Mechanism of Action: How It Works Semaglutide is not a stimulant

Clinical significance of these heart rate changes remains an area of ongoing research
It does not directly increase energy expenditure

Samec, M., Liskova, A., Koklesova, L., Samuel, S
Asthma exacerbation counts were lower in those patients who started GLP-1 RAs (reference) compared with SGLT-2 inhibitors [incidence rate ratio (IRR), 2.98

Nakamori H, Iida K, Hashitani H