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Drug Design, Development and Therapy

Lack of patient adherence or persistence on the medications implies that for many patients, short-term gains in weight loss and other benefits could evaporate

Arteries and veins lose their elasticity, leading to increased vascular stiffness, which can result in higher blood pressure and a higher risk of cardiovascular diseases

Due to the cost of semaglutide, particularly in the United States, limited cost effectiveness analyses have demonstrated unfavorable incremental cost-effectiveness ratios for semaglutide relative to phentermine-topiramate as an alternative antiobesity medication in adolescents [41]

Your doctor will weigh benefits vs risks based on your individual situation

However, its usefulness for progressed DKD and established CVD remains unclear