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Semaglutide requires caution in patients with personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, and severe gastroparesis

Caution is also warranted when dismissing smaller quantitative sex differences in the therapeutic or adverse effect outcomes, especially considering the staggeringly large numbers of patients taking GLP-1-based therapeutics

Obesity 31 , 22492259 (2023)

All studies had estimands which aligned with the definitions of treatment regimen and efficacy estimands, except for SCALE Obesity and Prediabetes which did not report on the efficacy estimand

While fatigue is not among the most commonly reported side effects, some individuals do experience a sense of tiredness during the course of treatment

Appetite and portion control improvements 4