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Once released, GLP-1 enters the bloodstream and attaches to specific GLP-1 receptors

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GLP-1 drugs are expensive, with list prices exceeding $1,000/month in many markets, and studies consistently show that people who stop taking semaglutide regain roughly two-thirds of the weight they lost, raising fundamental questions about whether these drugs represent treatment or lifelong pharmaceutical dependency

Urine color and recent fluid loss can help explain a temporary change

Avoid blowing on the area or injecting while its still wet, as this can cause unnecessary irritation

313,314 In one study, OA was induced in rats by injecting MIA into the knee joint, mimicking the pathological changes of human OA