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Funding Statement This research was funded by the Pioneer and Leading Goose R&D Program of Zhejiang Province (No

15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction

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However, some patients reported reduced appetite and gastrointestinal discomfort, which may impact tolerability

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By combining semaglutide with cagrilintide (an amylin receptor agonist), this therapy has delivered weight loss results exceeding 20% in clinical trials