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GLP-1 drugs also reduce levels of the hormone glucagon, which can raise blood sugar

According to another analysis [34], the published results, as a rule, show an improvement in some brain parameters (for example, hippocampal connectivity, glucose metabolism in the brain, hippocampal activation according to functional magnetic resonance imaging), but could not demonstrate a strong correlation with cognitive indicators

doi:10.1038/s41572-021-00293-y 8

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These findings illustrate the role of mitochondrial defects in increasing oxidative stress and reducing ATP synthesis, which leads to increased neuronal vulnerability

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