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To test the local effects of GLP-1(736) and exendin 939 on heat sensitivity, PWL was measured via the Hargreaves radiant heat apparatus following intraplantar administration of 10 g of GLP-1(736) or vehicle (0.9% saline) ( n = 5 per group) in a volume of 10 L

Finally, in clinical practice, some medications used to treat addiction can also affect appetite and body weight

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They cannot address significant skin excess or replace the dramatic improvement that surgery provides for patients with substantial laxity

Muscle and bone loss that can accompany rapid weight loss (as is common with GLP-1 use) can increase the risk of falls and fractures in older adults who are already at risk due to age-related deterioration