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Description
Acta como agonista triple de los receptores GLP-1, GIP y glucagn, amplificando la respuesta natural del organismo en la regulacin del apetito, la glucosa y el metabolismo de las grasas

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In a mouse model of acute inflammation in vivo , with the treatment of sommarutide, circulating concentrations of pro-inflammatory cytokines, including TNF- and IFN-, were decreased, accompanied by attenuated infiltration of immune effector cells ( 2.2.1 Autophagy Autophagy is an evolutionarily conserved catabolic process essential for cellular homeostasis during stress conditions, including nutrient deprivation and hypoxia

In humans, L585 cleavage by CPA reduces the plasma half-life of albumin from 3 weeks to 3.5 days due to loss of FcRn binding affinity 60

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Eli Lilly produces name-brand tirzepatide (Mounjaro, Zepbound) and dulaglutide (Trulicity)