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Abstract Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways

NICE in the UK recommends a maximum of two years for semaglutide (Wegovy), though no such limit exists for tirzepatide (Mounjaro)

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When body weight comes down, insulin control can improve, and cycles may become more predictable over time
