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This timeline allows for stable establishment of probiotic strains, consistent production of bacterial metabolites, time for downstream metabolic effects to potentially emerge, and enough consistency to assess subjective changes in appetite, energy, and wellbeing

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Instead of testing people taking medicines, researchers used a technique called "drug-target Mendelian randomization," which examines naturally occurring genetic differences that mimic the biological effects of GLP-1 receptor activation

High bioavailability, strong protein binding, and long half-lives allow even small amounts of GLP-1s to sustain meaningful receptor activation

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