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Towards tailored obesity treatment choices based on obesity-related complications Ectopic fat deposition in different organs results over time in progressive metabolic dysfunction and the development of organ-specific metabolic complications including T2D, MASLD/MASH and HFpEF [108]

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Finally, the role of GLP-1 in the thyroid gland remains to be determined, although GLP-1R expression analyses indicate this is largely a rodent phenomenon [19], [20]

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New techniques for improving knowledge about intestinal peptides Despite the advances made in Mutt's laboratory, the isolation and purification of intestinal peptide hormones was time-consuming and expensive

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Altered neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model

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