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2021: STEP Changes the Game The STEP trials brought semaglutide into the spotlight

[23] This reduces metabolic efficacy, harms your gut microbiome, and reduces the hormones needed for health: leptin, ghrelin, insulin, cortisol, thyroid, etc

Semaglutide may be appropriate for men who have difficulty managing weight despite lifestyle changes

Adherence in trials is artificially high for instance, 92.8% of patients in a 2-year semaglutide trial completed the study (source)

If the observed benefit of GLP-1 receptor agonists disappears or weakens meaningfully when compared with another contemporary metabolic therapy, then the story becomes less about a unique anticancer effect and more about broader metabolic optimization, comparator selection, or residual differences between treatment populations