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By improving insulin sensitivity and reducing excess adipose tissue, GLP-1s may indirectly decrease estrogen-driven inflammation for some patients

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All this to say, these primary actions are why GLP-1 medications exist and are prescribed

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Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]
