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King A, Miller EM

Due to these characteristics, albumin-binding DARPins are a potential substitute scaffold for extending the half-life of therapeutic proteins and peptides

[99], which involved transplantations of fecal microbiota obtained from depressed patients into a microbiota-depleted antibiotic rat model, the animals developed depressive-like symptoms, which were manifested by behavioral differences such as decreased sucrose intake in the sucrose preference test, a lower number of entries to an open arm in the elevated plus-maze test, and an increase in a plasma kynurenine/tryptophan ratio

These effects contribute to weight loss that varies by agent and dosetypically ranging from 5-8% with liraglutide 3 mg (Saxenda), up to 15% with semaglutide 2.4 mg (Wegovy), and potentially up to 20% with higher doses of tirzepatide (Zepbound)

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