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Description
Retatrutide alone produced roughly 24% mean weight loss in its Phase 2 trial without any second agent

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Initial analysis of new GLP-1 receptor agonist users suggested these patients were disproportionately female (59.6% vs 35.5%), non-Hispanic White (68.7%), and persons with a BMI of 30 kg/m2 or greater (63.5%)

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81 The microbiome and immune system engage in bidirectional communication, with dysbiotic microbiota from IBD patients or colitis models shown to exacerbate or induce inflammation when transferred to healthy or susceptible hosts