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DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

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Another meta-analysis, including a total of 1,101 adult participants with type 2 diabetes or prediabetes, demonstrated that intermittent fasting (IF) led to significant reductions in body weight (4.56 kg), body mass index (1.99 kg/m 2 ), HbA1c (0.81%), fasting glucose (0.36 mmol/L), total cholesterol (0.31 mmol/L), and triglycerides (0.14 mmol/L), without exerting a significant impact on fat mass, insulin levels, LDL, HDL, or blood pressure compared to control groups (133)

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Pharmacological studies have also found that hehuan yin tang and yijing tang, as key components of various TCM prescriptions, can regulate androgen and insulin levels and improve PCOS-IR symptoms through various pharmacological pathways [207, 223]