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56 In patients with prediabetes, there is a characteristic loss of first phase GSIS that can be restored quickly under conditions of administered GLP-1

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However, symptom heterogeneity and overlap with other non-immunological food sensitivities, combined with the absence of standardized diagnostic criteria and validated testing protocols, continue to obscure its classification

It is possible that subpopulations of these cells exist, each with distinct roles in energy homeostasis