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Side effects were mainly gastrointestinal, generally mild to moderate, and led to discontinuation in up to 10% of patients

Now, clean the top of the vial with an alcohol wipe

6 Federal law mandates the existence of black-box warnings, stating in part that, special problems, particularly those that may lead to death or serious injury, may be required by the [FDA] to be placed in a prominently displayed box (21 CFR 201.57(e))

Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, et al

Promising drug categories include: cholesterol-lowering drugs (e.g., aramchol), 104 FXR agonists (e.g., obeticholic acid, 105 tropifexor), 106 PPAR agonists [e.g., elafibranor (PPAR /), 107 saroglitazar (PPAR /), 108 pemafibrate (PPAR) 109 ], Thyroid hormone receptor agonists (e.g., resmetirom), 110 and FGF21 analog (e.g., pegbelfermin)

These improvements occurred alongside weight loss and were dose-dependent, meaning higher doses typically produced greater lipid improvements