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These modifications of the receptor had no effect on ligand binding and receptor activation 15,19

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Anyone facing surgery or endoscopy should tell their doctor, as the dose may need to be paused

Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

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