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2018), others reported that the loss of whole-body Gipr and selective loss of cardiomyocyte Gipr expression in MerCreMer transgenic mice expressing tamoxifen-inducible Cre was reported to be cardioprotective in mice (Pujadas et al

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Safety concerns were also raised in a phase 1 trial investigating the GLP-1R/GCGR agonist NNC9204-117, where a dose-dependent increase in heart rate was observed, in addition to increased markers of inflammation, hepatic disturbances, impaired glucose tolerance, and reduced blood levels of some amino acids despite clinically relevant weight loss (Friedrichsen et al

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