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The systemic bioavailability of resveratrol is very low and administration of high doses is needed to reach a significant concentration in the blood [76] due to rapid metabolization in the intestine and the liver [77]

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Kadaja M, Keyes BE, Lin M, Pasolli HA, Genander M, Polak L, Stokes N, Zheng D, Fuchs E

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Intranasal drug delivery of sumatriptan succinate-loaded polymeric solid lipid nanoparticles for brain targeting

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