glp-1 ra therapy Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes GLP-1 Genetics: How Genes Affect

2016;24:195561

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We sought to investigate the real-world impact of sodiumglucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy in individuals with type 1 diabetes in relation to effect on blood glucose levels, adverse events and cardio-renal outcomes

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NIT-1 cells treated with PA+Ex-4 and PA+GW showed enhanced GSIS capacity, increased PPAR expression, decreased UCP2 expression and ADP/ATP ratio, and improved mitochondrial DNA content and mitochondrial membrane potential compared with those treated with PA alone, whereas the opposite results were observed in the PA+GSK group

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