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GLP-1 patches remain investigational, though some research shows promise for weight management and blood sugar control

Citing its post-market evaluation that found no increased risk of suicidal ideation or behavior, the U.S

Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence

In addition, glucagon like peptide 1 (GLP-1) receptor agonists, dual GLP-1 receptor and GIP receptor agonists, and pramlintide can be administered by injection

Multivariate analysis showed no difference between placebo and liraglutide arms in HbA1c at 6 months (HbA1c:0.2mmol/mol, 11.3, 11.6, p=0.98) however, at 12 months HbA1c was significantly higher in the liraglutide arm (HbA1c:10.9mmol/mol, 1.1, 20.6, p=0.032)

It is the first GLP-1 pill approved for losing excess weight.