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Induction of CCK and GLP-1 release in enteroendocrine cells by egg white peptides generated during gastrointestinal digestion

BMJ 344:d7771 Correale M, Monaco I, Brunetti ND, Di Biase M, Metra M, Nodari S, Butler J, Gheorghiade M (2018) Master Program Students on Drug Development for Heart Failure

GLP-1 receptor agonists work by mimicking the naturally occurring hormone glucagon-like peptide-1, which slows gastric emptying, increases satiety, and reduces appetite

In both the trial-product and treatment-policy estimand analyses, all oral semaglutide groups demonstrated a significantly greater reduction in A1C from baseline when compared with placebo at 26 and 52 weeks

But, over time, newer, more advanced GLP-1s have come to market, with even longer release times (no offense, Gila monsters)

The panel dove deep into affordability, access to care challenges, and side effects that serve as barriers to treatment