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Semaglutide oral is co-formulated with sodium N-(8-[8-[2-hydroxybenzoyl]amino) caprylate (sodium salcaprozate or SNAC) which allows absorption of semaglutide across the gastric mucosa

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There was no significant difference in GFAP percentage area stained with 9.2 1.6%, 8.8 2.2% and 8.8 2.0% area coverage for vehicle dosed, 25 nmol/kg and 75 nmol/kg liraglutide dosed respectively ( P = 0.7824, one-way ANOVA) (Fig