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Step five: the escalation schedule Once you have established your starting dose, follow a 4-week escalation pattern

Nadolsky says that for some of his patients at the highest dose of tirzepatide, the drug is sometimes "dampening that dopamine reward system down so much that now, instead of just getting away from those addictive behaviors, they don't feel like doing anything." Some of those high-dose patients start seeking out sugar, not due to cravings, he says, but because their bodies are searching for some kind of stimulation to get the reward system going again

Drugs with differing access to the brain may have different effects, he pointed out

This is basically asking your insurance company for permission to cover the medication, especially if it's not automatically on their list of approved drugs

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