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pmid:27507209
The real problem seems to be retention
It increases caloric expenditure directly while also preserving metabolically active muscle tissue
Because it activates three receptor pathways, the dose-response curve is steeper and the side effect profile is more sensitive to sudden increases
Biochim Biophys Acta (2005) 1751:3344
Lifestyle factors overlay on top of genetic predisposition: consistent meal timing, adequate protein intake, stress management, and regular movement all accelerate weight loss timelines
