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Tirzepatide for Weight Loss Maintenance Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial, Lancet (2026) [PubMed abstract] BIBLIOGRAPHY 1 - Zepbound PI 2 - PMID 34170647 - Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes, NEJM (2021) 3 - PMID 35133415 - Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial, JAMA (2022) 4 - North Carolina Pharmacy Practice Act

The data is clear: your choice between tirzepatide and semaglutide should be based on your specific weight loss goals, tolerability, and metabolic needsnot on muscle preservation

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They work by enhancing natural hormonal pathways that control hunger, blood sugar, and metabolism
Andersen A, Lund A, Knop FK, Vilsboll T (2018) Glucagon-like peptide 1 in health and disease

Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinsons Disease by GLP-1 Secretion
