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how were glp 1 agonists discovered Understanding GLP-1 receptor and their impact on drug discovery Current Insights, Advantages and Challenges
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doi:10.1210/er.2018-00168 173

In the heart, GLP-1 binding to its receptor enhances myocardial performance and has important physiological effects on cardiac function through direct receptor-mediated [21-24]

Ltd., Pfizer Inc., Amgen Inc., Innovent Biologics Inc., Jiangsu Hengrui Medicine Co., Sun Pharmaceuticals Industries Ltd., PegBio Co
doi: 10.1016/j.ygyno.2024.07.008 [DOI] [PubMed] [Google Scholar] 34.He W, Yu S, Wang L, et al

Notably, a dose-dependent increase in heart rate, peaking at 24 weeks, subsequently decreased [19]

doi: 10.1007/s005920050116