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The use of gut-hormone receptors agonists as new therapeutic options for obesity and some of its related comorbidities, such as type 2 diabetes, has resulted in an unprecedented efficacy in the medical management of people living with obesity (PLWO)

Co-primary endpoints were changes from baseline to end of treatment in the first (AUC010 min) and second (AUC10120 min) insulin secretion phases, as measured by the IVGTT

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Non-obese diabetic mice aged 7 weeks were treated for 1 week with JD-5037, then euthanised

GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation