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Results Semaglutide exposure (area under the plasma concentrationtime curve from time zero to 24 h after the tenth dose and maximum concentration after the tenth dose) did not vary in a consistent pattern across the renal function groups

Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain

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GLP-1 medications were originally designed as medical tools for diabetes management, not quick fixes for poor metabolic habits