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Description
29 January 2020
PMC 11751538
This systemic nature necessitates therapeutic approaches that address both hepatic and extra-hepatic metabolic abnormalities, positioning incretin-based therapies as particularly promising interventions [2]
Takeda et al crossed Alzheimer transgenic mice (APP23) with two types of diabetic mice (ob/ob and NSY mice) and found a significant increase in IL-6 in the brains of hybrid mice fed with a high-fat diet
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This is the largest pharmacological liver-fat effect reported in any clinical trial to date
