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The authors are renowned researchers and clinicians, and although most declare that they have no conflicts of interest, their scientific reputation fully supports the design of the algorithm they developed. What new information does it offer compared to previous research

Human and animal rights The study was registered at ClincialTrials.gov (ID: NCT04238702)

Together, the binding and activation of the two different receptors complement each other to regulate appetite, insulin sensitivity and insulin release

Patients with certain genetic profiles may benefit from even slower dose escalation or alternative formulations, such as compounded oral tirzepatide instead of injection

To view a copy of this licence, visit About this article Cite this article Pratley, R.E., Crowley, M.J., Gislum, M
