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GLP-1 stimulation induced serine phosphorylation of wild-type GLP-1R, which was abolished in all individual doublet as well as triple doublet phospho-null mutants

Restrictions create a challenge for manufacturers and patients alike

Roche reported positive Phase II topline data showing that its once-weekly dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist CT-388 achieved substantial, sustained, and dose-dependent weight loss through 48 weeks

Results Mean baseline age was 47 years, 63% were female, BMI was 40 kg/m2, and HbA1c was 5.86%