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Description
42% greater weight reduction with RYBELSUS 14 mg than liraglutide 1.8 mg PIONEER 4 study design 1,6 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 711 adult patients with type 2 diabetes on metformin alone or metformin with an SGLT-2i were randomized to RYBELSUS 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily

The triple-agonist profile of retatrutide may offer better appetite regulation and mood-energy synergy

If you miss more than one menstrual cycle or develop additional symptoms, speak with a healthcare provider for further evaluation

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Serious complications are rare: pancreatitis at 0.3%, gallbladder events at 1.4%, and acute kidney injury at 0.7% (all associated with dehydration)
