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For example, in the case of amylin biology, significant translational gaps between rodent and human systems persist, the optimal receptor selectivity profile for clinical use remains unclear, and molecules continue to advance in clinical development despite these uncertainties ( 3.4 Changing clinical and regulatory expectations Finally, shifts in clinical and regulatory expectations have altered the landscape in which peptide therapeutics are evaluated

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Chronic pancreatitis is caused by repetitive episodes of pancreatic inflammation that lead to extensive fibrotic tissue replacement, and no curative treatment is available ( 2 Methods 2.1 Study design and settings This observational pharmacovigilance study used the FAERS database, which is a publicly available post-marketing safety surveillance database

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