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Fatty infiltration of the pancreas promotes impaired pancreatic -cell function and gradual hyperglycemia, which will further enhance de novo hepatic lipogenesis and promote higher NEFAs levels to the circulation (the twin cycle hypothesis) [18]
Clinical utility of dipeptidyl peptidase-4 inhibitors: A descriptive summary of current efficacy trials

Lancet Diabetes endocrinol (2019) 7(10):77685

The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: A systematic review and meta-analysis

But Pang adds that the hormone also acts on parts of the brain that control seemingly disparate mental processes, such as the mesolimbicor rewardsystem and the hippocampus, a learning and memory center that many neurological and psychiatric disorders affect

Retrieved 7 May 2026